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A corrupt, eccentric, and violently unpredictable DEA agent. He is the mastermind behind the murder of Mathilda's family and the primary antagonist.

An Italian-American mafia boss who acts as Leon's handler, providing him with hits and managing his finances. He operates out of a restaurant in Little Italy.

A cynical 12-year-old girl whose family was murdered by corrupt DEA agents. She seeks refuge with Leon and begs him to teach her his deadly trade so she can avenge her little brother.

A highly skilled but emotionally distant hitman known as a 'cleaner'. He lives a solitary life in Little Italy, New York, until a tragic event forces him to break his own rules.